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Immobilized polysaccharide CSPs

Chiral Technologies

Chromatography of chiral molecules is a simple, elegant technique for rapidly isolating enantiomers of high purity. It relies on chiral stationary phases (CSPs) designed specifically to separate chiral molecules, and Daicel CSPs are the most widely used in the pharmaceutical industry.

Immobilized polysaccharide CSPs from Chiral Technologies

The advent of immobilized polysaccharide CSPs (CHIRALPAK® IA, IB, IC, ID, IE and IF) lets chemists choose from a large assortment of organic solvents as mobile phases and better control compound solubility. The result is new separations with high levels of enantioselective recognition.

Chiral selectors

Each phase pairs an amylose or cellulose backbone with a carbamate selector. Phases marked with an asterisk use unique chiral selectors.

* Unique chiral selectors

Immobilized stationary phases

AttributeImmobilized selectors
ReliabilityAuthentic Daicel selectors
RobustnessSolvent flexibility
ReproducibilityEasy column regeneration
Loading capacityHigh loading capacity, greatly improved by analyte solubility

Complementarity

Each phase brings different selectivity. These example separations compare all six immobilized columns, with the best-performing column highlighted.

CHIRALPAK® IA · Meclizine
CHIRALPAK® IA · γ-Phenyl-γ-butyrolactone
CHIRALPAK® IB · Indapamide
CHIRALPAK® IC · 5-Benzylhydantoin
CHIRALPAK® ID · Amlodipine
CHIRALPAK® ID · Cisapride
CHIRALPAK® IE · Cetirizine
CHIRALPAK® IF · Methyclothiazide

Screen chiral columns automatically

Install up to ten CHIRALPAK® columns on the MCCPS System and screen them all in a single run.